Strictly polyphosphate-dependent glucokinase in a polyphosphate-accumulating bacterium, Microlunatus phosphovorus.

نویسندگان

  • Shotaro Tanaka
  • Sun-Og Lee
  • Kazuhiro Hamaoka
  • Junichi Kato
  • Noboru Takiguchi
  • Kazunori Nakamura
  • Hisao Ohtake
  • Akio Kuroda
چکیده

ATP-dependent glucokinase is suggested to have evolved from a hypothetical polyphosphate (polyP)-dependent glucokinase (polyP-GK) via a bifunctional polyP/ATP glucokinase (polyP/ATP-GK). Here we showed that polyP-GK is present in a polyP-accumulating bacterium, Microlunatus phosphovorus. The polyP-GK produced glucose-6-P(i) from glucose and polyP, but it could not phosphorylate glucose with ATP. The polyP-GK was most closely related to the polyP/ATP-GK of Mycobacterium tuberculosis.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 185 18  شماره 

صفحات  -

تاریخ انتشار 2003